Research at the Warren Lab

The Warren lab is a cross-disciplinary research lab attempting to understand the role vascular smooth muscle cells play in ageing and disease. We use a range of traditional molecular biology techniques alongside our novel hydrogel cell-culture system.

Publications

A scientist from The Warren Lab looking through a microscope

Active & Past Projects

Derek Warren, Stuart Rushworth, Andy Round
British Heart Foundation
1/10/24 → 30/09/27
Funding: £122,688.82
Derek Warren
The Big C Appeal
4/07/22 → 28/08/22
Funding: £1,400.00
Derek Warren
Biotechnology and Biological Sciences Research Council
9/03/20 → 5/04/23
Funding: £421,252.80
Derek Warren
Diabetes UK (The British Diabetic Association)
3/02/20 → 2/08/21
Funding: £14,108.30
Derek Warren & Samuel Fountain
British Heart Foundation
1/10/18 → 30/03/22
Funding: £118,726.01
Derek Warren & Samuel Fountain
British Heart Foundation
1/10/17 → 31/12/20
Funding: £111,347.00

Research at the Warren Lab

Active & Past Projects

Piezo1 and aquaporin-1 regulate matrix stiffness driven vascular smooth muscle cell hypertrophy

Does increased matrix stiffness within the tumour microenvironment switch endothelial cells into a pro-angiogenic / pro-tumourigenic state?

Molecular mechanisms coupling matrix rigidity to DNA damage in smooth muscle.

To understand mechanisms regulating smooth muscle cell stiffness in people with diabetes

The impact of matrix stiffness on smooth muscle cell contractile function

Does enhanced smooth muscle cell contraction increase local matrix stiffness and promote smooth muscle cell proliferation?

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